Name: Diosmin
CAS#: 520-27-4
Botanical Source: Immature bitter orange
Specification: EP, HPLC 90%--98%, Micronized Powder or Granule
Function & Application: Diosmin can protect blood vessel, enhance blood vessel tension, reduce capillary permeability, strengthen its resistance, invrease lymphatic drainage speed and its effect of contraction.
| TEST ITEM | STANDARD | RESULT |
| Appearance | Greyish-yellow or light yellow hygroscopic powder | Complies (Visual) |
| Melting point | 277℃-278℃ | Complies(Melting point apparatus) |
| Identification | (a)(b) Must Positive | Complies |
| Solubility | ||
| - in water | Insoluble | Complies |
| - in dimethyl sulfoxide | Soluble | Complies |
| - alcohol | Insoluble | |
| - dilute solutions of alkali hydroxides | Soluble | |
| Residue on ignition | ≤0.5% | Complies |
| Mesh size | 100% pass 80 mesh/2000 mesh | Complies |
| Iodine | ≤0.1% | Complies (Potentiostat) |
| Related substances | ||
| - acetoisovanillone | ≤0.5% | Complies (HPLC) |
| - hesperidin | ≤4.0% | Complies (HPLC) |
| - isorhoifolin | ≤3.0% | Complies (HPLC) |
| - 6-iododiosmin | ≤0.6% | Complies (HPLC) |
| - linarin | ≤3.0% | Complies (HPLC) |
| - diosmetin | ≤2.0% | Complies (HPLC) |
| - unspecified impurities | ≤0.4% | Complies (HPLC) |
| - total | ≤8.5% | Complies (HPLC) |
| Heavy metals | 90%---102% | Complies (HPLC) |
| Water | ≤6.0% | Complies (K.F) |
| Residual solvents | ||
| - methanol | ≤3000ppm | Complies (HPGC) |
| - acetic acid | ≤5000ppm | Complies (HPGC) |
| - pyridine | ≤200ppm | Complies (HPGC) |
| Assay | ||
| MICROBIOLOGICAL TEST | STANDARD | RESULT |
| Total microbial count | ≤1000cfu/g | Complies |
| Yeast & mold | ≤100cfu/g | Complies |
| E.Coli | Negative | Negative |
| Salmonella | Negative | Negative |
Packaging: The usual packaging is 25kg net carton drum or box with a polyethylene bag in side.
Storage: Preserve in well closed,light resistant and dry environment.
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